There have been reports of both autosomal dominant inheritance and autosomal recessive inheritance. ![]() There are a number of genes that have changes that can cause an Adrenocortical carcinoma, including TP53 and IGF2. Adrenocortical carcinoma may develop by chance alone, but at least 50% of the cancers are thought to be hereditary. These symptoms are due to the tumors causing excess secretion of hormones from the adrenal glands. Symptoms of Adrenocortical carcinoma may include pain in the abdomen, hypertension, weight gain, frequent urination and possibly deepening of the voice. These glands are on top of each kidney and are responsible for producing certain hormones and keeping blood pressure at normal levels. ![]() Adrenocortical carcinoma is a rare cancer affecting the outside of the adrenal glands (adrenal cortex).
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